Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
Ocul Immunol Inflamm. 2020;28(1):92-99. doi: 10.1080/09273948.2018.1535080. Epub 2018 Oct 18.
: To analyze the pattern of laboratory investigations of uveitis at a tertiary referral eye care center in Singapore.: Retrospective analysis of 2040 uveitis cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database over a 12-year period (2004 - 2015).: Patients with retinal vasculitis (RV) had the most tests utilized per patient (6.79), followed by intermediate uveitis (IU) (5.25), panuveitis (Pan) (5.12), posterior uveitis (PU) (4.17), anterior uveitis (AU) (2.75), and keratouveitis (KU) (1.10). The most frequently utilized test for infective etiology were the VDRL (41.3%), Syphilis IgG (29.5%), and T-SPOT.TB (24.6%). For autoimmune tests, ANA was most utilized (18.2%), followed by anti-dsDNA (14.8%), and HLA-B27 (12.4%).: There was high utilization of autoimmune tests such as ANA, anti-dsDNA, RF, and ANCA, despite its limited yield. Rationalization of investigations in patients with ocular inflammation via a stepladder approach may help optimize the use of limited resources.
: 分析新加坡一家三级转诊眼科中心葡萄膜炎的实验室检查模式。: 对 OASIS 数据库中 2040 例葡萄膜炎病例进行了 12 年的回顾性分析（2004-2015 年）。: 视网膜血管炎（RV）患者的人均检查项目最多（6.79 项），其次是中间葡萄膜炎（IU）（5.25 项）、全葡萄膜炎（Pan）（5.12 项）、后葡萄膜炎（PU）（4.17 项）、前葡萄膜炎（AU）（2.75 项）和角膜葡萄膜炎（KU）（1.10 项）。用于感染性病因的最常用检查是 VDRL（41.3%）、梅毒 IgG（29.5%）和 T-SPOT.TB（24.6%）。对于自身免疫性检查，ANA 的使用率最高（18.2%），其次是抗 dsDNA（14.8%）和 HLA-B27（12.4%）。: 尽管自身免疫性检查的收益有限，但仍大量使用了 ANA、抗 dsDNA、RF 和 ANCA 等自身免疫性检查。通过逐步检查的方法对眼部炎症患者进行检查，可以帮助优化有限资源的利用。
