Hassan Haseena, Cotton Mark F, Rabie Helena
From the *Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children's Hospital; and †Children's Infectious Diseases Research Unit (KIDCRU), Stellenbosch University, Tygerberg, Cape Town, South Africa.
Pediatr Infect Dis J. 2015 Jan;34(1):62-5. doi: 10.1097/INF.0000000000000480.
We report 7 HIV-infected children with cryptococcosis. Median age and CD4 counts were 9.3 years and 12 cells/mm, respectively. Two children died early. Of 4 children requiring prolonged amphotericin B and fluconazole at a dosage above 12 mg/kg/d, 3 presented with meningitis and 1 with fever. Immune reconstitution inflammatory syndrome contributed to morbidity through exacerbations at the primary site and elsewhere.
我们报告了7例感染HIV的隐球菌病患儿。中位年龄和CD4细胞计数分别为9.3岁和12个细胞/立方毫米。2名儿童早期死亡。在4例需要长期使用两性霉素B和氟康唑且剂量高于12mg/kg/天的儿童中，3例患有脑膜炎，1例发热。免疫重建炎症综合征通过原发部位及其他部位的病情加重导致发病。
