Frontier Research Core for Life Sciences, University of Toyama, Toyama 930-0194, Japan.
Paul F. Glenn Laboratory for the Science of Aging and Department of Biology, and The Koch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell Metab. 2014 Jul 1;20(1):192-192.e1. doi: 10.1016/j.cmet.2014.06.001.
Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD)-dependent enzymes that regulate a wide range of biological processes, including aging, in several species. This SnapShot provides a comprehensive overview of the targets, enzymatic activities, and physiological functions of the seven mammalian sirtuins, as well as the regulation of the biosynthetic pathways regulating NAD availability.
Sirtuins 是高度保守的烟酰胺腺嘌呤二核苷酸 (NAD) 依赖性酶，可调节包括衰老在内的多种物种中的多种生物学过程。这个 SnapShot 全面概述了七种哺乳动物 Sirtuins 的靶标、酶活性和生理功能，以及调节 NAD 可用性的生物合成途径的调节。
