通过芳炔插入二甲基亚砜的S═O键引发的三组分偶联反应。
Three-component coupling reaction triggered by insertion of arynes into the S═O bond of DMSO.
作者信息
Liu Feng-Lei, Chen Jia-Rong, Zou You-Quan, Wei Qiang, Xiao Wen-Jing
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Wuhan, Hubei 430079, China.
出版信息
Org Lett. 2014 Jul 18;16(14):3768-71. doi: 10.1021/ol501638x. Epub 2014 Jul 2.
An unprecedented three-component coupling reaction of arynes, α-bromo carbonyl compounds, and DMSO triggered by insertion of arynes into the S═O bond of DMSO has been developed. The reaction can generate a wide range of multisubstituted aryl methyl thioethers in good yields, wherein DMSO serves as both methylthiolation reagent and oxygen source.
一种前所未有的由芳炔插入二甲基亚砜（DMSO）的S═O键引发的芳炔、α-溴代羰基化合物和DMSO的三组分偶联反应已被开发出来。该反应能够以良好的产率生成多种多取代芳基甲基硫醚，其中DMSO既作为甲硫基化试剂又作为氧源。
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