Gaykar Rahul N, Guin Avishek, Bhattacharjee Subrata, Biju Akkattu T
Department of Organic Chemistry , Indian Institute of Science , Bangalore - 560012 , India.
Org Lett. 2019 Dec 6;21(23):9613-9617. doi: 10.1021/acs.orglett.9b03789. Epub 2019 Nov 14.
The three-component coupling of tertiary amines, arynes, and aryl selenium bromide or diaryl diselenide as an electrophilic selenium source allowing the synthesis of 2-selanyl aniline derivatives is reported. This aminoselenation reaction of arynes installs a C-N and C-Se bond under mild conditions, and the products are formed in moderate to good yields. This reaction is compatible with various functional groups, and the preliminary studies on the mechanism of the reaction is also provided.
据报道，叔胺、芳炔与作为亲电硒源的芳基硒溴或二芳基二硒醚发生三组分偶联反应，可合成2-硒基苯胺衍生物。芳炔的这种氨基硒化反应在温和条件下形成C-N键和C-Se键，产物收率中等至良好。该反应与各种官能团兼容，并且还提供了对反应机理的初步研究。
