钙黏蛋白：语言能力中的潜在调节因子。

Cadherins: potential regulators in the faculty of language.

作者信息

Matsunaga Eiji, Okanoya Kazuo

机构信息

Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, Japan.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan; ERATO Okanoya Emotional Information Project, JST-ERATO, Japan; Emotional Information Joint Research Laboratory, RIKEN Brain Science Institute, Japan.

出版信息

Curr Opin Neurobiol. 2014 Oct;28:28-33. doi: 10.1016/j.conb.2014.06.001. Epub 2014 Jun 29.

DOI:10.1016/j.conb.2014.06.001

PMID:24988490

Abstract

The cadherin superfamily is a large (now more than 100 proteins) protein family originally identified as cell adhesion molecules. Each cadherin shows distinct expression patterns in the nervous system, and their expressions are both spatially and temporally regulated and diverse among different species. Mounting evidence has suggested that cadherins play multiple roles in neural development and functions. Recently, using songbirds and mice, the potential role of cadherins in vocal behavior has been demonstrated. Here, we will briefly introduce general function of cadherins, and analyze the potential involvement of cadherins in vocal behaviors and their evolution.

摘要

钙黏蛋白超家族是一个庞大的蛋白质家族（目前有超过100种蛋白质），最初被鉴定为细胞黏附分子。每种钙黏蛋白在神经系统中都表现出独特的表达模式，其表达在空间和时间上受到调控，并且在不同物种之间存在差异。越来越多的证据表明，钙黏蛋白在神经发育和功能中发挥多种作用。最近，利用鸣禽和小鼠，已经证明了钙黏蛋白在发声行为中的潜在作用。在这里，我们将简要介绍钙黏蛋白的一般功能，并分析钙黏蛋白在发声行为及其进化中的潜在参与情况。