Kicielińska Jagoda, Pajtasz-Piasecka Elzbieta
Postepy Hig Med Dosw (Online). 2014;68:879-92. doi: 10.5604/17322693.1111123.
Under the influence of the various stimuli that activate transcription factors such as cMaf, NFIL3, and ERK, many normal and neoplastic cells are able to produce the same cytokine--IL-10. There is increasing evidence that this cytokine has a significant impact on various aspects of the immune control mechanisms. Therefore, it is important to complete understanding of which factors are responsible for regulation of Il10 gene expression and protein secretion. The influence of IL-10 on cells, as in the case of other cytokines, depends on the presence of the specific receptor. Its expression has been shown, among others, on the surface of antigen-presenting cells (dendritic cells, macrophages, B cells), NK cells, T lymphocytes CD8+ and CD4+ (including Tr1, Th1 and Th2), which play an important role in the development of anti-tumor immunity. Therefore, the role of IL-10 in this process is considered to an increasing extent. There are a number of results showing that IL-10 is involved in the generation of immunosuppression, while others demonstrate immunostimulatory properties of this cytokine. This functional duality of IL-10 is substantial in the context of the regulation of tumor growth, both its promotion and fighting against it.
在激活转录因子（如cMaf、NFIL3和ERK）的各种刺激影响下，许多正常细胞和肿瘤细胞都能够产生同一种细胞因子——白细胞介素-10（IL-10）。越来越多的证据表明，这种细胞因子对免疫控制机制的各个方面都有重大影响。因此，全面了解哪些因素负责调节Il10基因表达和蛋白质分泌非常重要。与其他细胞因子一样，IL-10对细胞的影响取决于特定受体的存在。研究表明，其表达存在于抗原呈递细胞（树突状细胞、巨噬细胞、B细胞）、自然杀伤细胞、CD8+和CD4+ T淋巴细胞（包括Tr1、Th1和Th2）表面，这些细胞在抗肿瘤免疫的发展中发挥着重要作用。因此，IL-10在这一过程中的作用越来越受到关注。有许多结果表明IL-10参与免疫抑制的产生，而其他一些结果则证明了这种细胞因子的免疫刺激特性。在肿瘤生长的调节方面，无论是促进还是对抗肿瘤生长，IL-10的这种功能二元性都至关重要。
