Dorozhkova I R, Karachunskiĭ M A, Abdullaeva E T, Gamzaeva N F, Kochetkova E Ia
Probl Tuberk. 1989(3):14-8.
To elucidate the role of tubercle bacilli L-forms in tuberculosis relapsing and aggravation in patients with extended residual lesions in the lungs, 117 patients mainly with extended and neglected destructive tuberculosis of the lungs were observed for a period of 5 to 7 years with using microbiological and clinico-roentgeno-laboratory examinations. Analysis of the immediate and remote results of the treatment showed that in the group of the abacillary patients according to the routine microbiological investigations who continued to isolate L-forms of tubercle bacilli at the background of remaining destructive cavities in the lungs aggravations and relapses amounted to 46.6 per cent. The etiological role of the L-forms was proved by absolute identity of the biological properties of the L-form revertants isolated from in vitro subcultures and tubercle bacilli, isolated from the patients during the process relapsing.
为阐明结核杆菌L型在肺部有广泛残留病变患者肺结核复发和病情加重中的作用，对117例主要为广泛性和未治疗的肺部破坏性肺结核患者进行了5至7年的观察，采用微生物学及临床X线 - 实验室检查。对治疗的近期和远期结果分析表明，在常规微生物学检查中无细菌生长但肺部仍有破坏性空洞且持续分离出结核杆菌L型的患者组中，病情加重和复发率达46.6%。从体外传代培养物中分离出的L型回复株与复发过程中从患者体内分离出的结核杆菌生物学特性完全相同，证实了L型的病因学作用。
