[精神分裂症患者白细胞介素-1β和吲哚胺2,3-双加氧酶基因多态性研究]

[A study of IL-1Β and IDO gene polymorphisms in patients with schizophrenia].

作者信息

Golimbet V E, Korovaĭtseva G I, Gabaeva M V, Velikaia N V, Snegireva A A, Kasparov S V, Kolesina N Iu, Ganisheva T K, Savel'eva T M

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(5):46-9.

PMID:24988959

Abstract

OBJECTIVE

Neurotoxic metabolites of the kynurenine pathway are thought to be implicated in the pathogenesis of schizophrenia. The enzyme indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step of the kynurenine pathway that converts tryptophan to kynurenine metabolites. IDO is induced by proinflammatory cytokines. We studied IL-1Β T-511C (rs16944), IL-1Β C3954T (rs1143634), IDO VNTR and IDO rs9657182 polymorphisms in patients with schizophrenia and controls.

MATERIAL AND METHODS

Genotyping was performed in 296 patients with schizophrenia (ICD-10 F20.0) and 355 healthy controls.

RESULTS

The multiple dimension reduction (MDR) analysis revealed a combination included alleles С (T-511C), Т (C3954T), V1 (VNTR) and С (rs9657182), which was associated with schizophrenia (OR 3,3 CI 95% 2,3-4,8).

CONCLUSION

This is the first report of the interaction between IL-1Β and IDO genes. Further research into genes of the kynurenine pathway is needed.

摘要

目的

犬尿氨酸途径的神经毒性代谢产物被认为与精神分裂症的发病机制有关。吲哚胺2,3-双加氧酶（IDO）催化犬尿氨酸途径的第一步，该步骤将色氨酸转化为犬尿氨酸代谢产物。IDO由促炎细胞因子诱导。我们研究了精神分裂症患者和对照组中白细胞介素-1β T-511C（rs16944）、白细胞介素-1β C3954T（rs1143634）、IDO可变数目串联重复序列（VNTR）以及IDO rs9657182基因多态性。