Lehr E
Department of Pharmacology, Boehringer Ingelheim, Federal Republic of Germany.
Psychopharmacology (Berl). 1989;97(2):145-6. doi: 10.1007/BF00442235.
Four-day-old chicks respond to isolation with distress calling. A decrease in distress calling during isolation seems to reflect some general aspect of depressive syndrome and appears to be sensitive to pharmacological manipulation. Diverse clinically active antidepressants are able to counteract this decrease with high selectivity; non-antidepressants have either no influence or further inhibit the distress calling.
4日龄雏鸡会通过发出求救叫声来回应隔离状态。隔离期间求救叫声的减少似乎反映了抑郁综合征的一些普遍特征,并且似乎对药物处理敏感。多种具有临床活性的抗抑郁药能够以高选择性抵消这种减少;非抗抑郁药要么没有影响,要么进一步抑制求救叫声。