使用传统X射线源的低剂量相衬断层扫描。
Low-dose phase contrast tomography with conventional x-ray sources.
作者信息
Hagen C K, Munro P R T, Endrizzi M, Diemoz P C, Olivo A
机构信息
Department of Medical Physics and Bioengineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.
Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia and Centre for Microscopy, Characterisation, and Analysis, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.
出版信息
Med Phys. 2014 Jul;41(7):070701. doi: 10.1118/1.4884297.
PURPOSE
The edge illumination (EI) x-ray phase contrast imaging (XPCi) method has been recently further developed to perform tomographic and, thus, volumetric imaging. In this paper, the first tomographic EI XPCi images acquired with a conventional x-ray source at dose levels below that used for preclinical small animal imaging are presented.
METHODS
Two test objects, a biological sample and a custom-built phantom, were imaged with a laboratory-based EI XPCi setup in tomography mode. Tomographic maps that show the phase shift and attenuating properties of the object were reconstructed, and analyzed in terms of signal-to-noise ratio and quantitative accuracy. Dose measurements using thermoluminescence devices were performed.
RESULTS
The obtained images demonstrate that phase based imaging methods can provide superior results compared to attenuation based modalities for weakly attenuating samples also in 3D. Moreover, and, most importantly, they demonstrate the feasibility of low-dose imaging. In addition, the experimental results can be considered quantitative within the constraints imposed by polychromaticity.
CONCLUSIONS
The results, together with the method's dose efficiency and compatibility with conventional x-ray sources, indicate that tomographic EI XPCi can become an important tool for the routine imaging of biomedical samples.
目的
边缘照明（EI）X射线相衬成像（XPCi）方法最近得到了进一步发展，可用于断层成像，进而实现体积成像。本文展示了使用传统X射线源在低于临床前小动物成像所用剂量水平下获取的首批断层EI XPCi图像。
方法
使用基于实验室的EI XPCi装置在断层成像模式下对两个测试对象（一个生物样本和一个定制体模）进行成像。重建了显示对象相移和衰减特性的断层图像，并从信噪比和定量准确性方面进行了分析。使用热释光装置进行了剂量测量。
结果
所获得的图像表明，对于弱衰减样本，基于相位的成像方法在三维情况下也能提供比基于衰减的成像方式更优的结果。此外，最重要的是，它们证明了低剂量成像的可行性。此外，在多色性所带来的限制范围内，实验结果可被视为定量的。
结论
这些结果，连同该方法的剂量效率以及与传统X射线源的兼容性，表明断层EI XPCi可成为生物医学样本常规成像的重要工具。
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