Hernandez L L, Valentine J D
Dorn Veterans' Hospital, Columbia, SC 29201.
Psychopharmacology (Berl). 1989;97(4):476-80. doi: 10.1007/BF00439551.
Rats were trained to bar-press for food and then received aversive Pavlovian conditioning following low doses of ethanol (0-1600 mg/kg in different groups). They were tested for Pavlovian conditioned suppression of bar-pressing 48 h, 7 days, and 14 days later following no additional differential treatments. The results showed that very low doses of ethanol (approximately 200 mg/kg) during training enhanced later conditioned suppression, whereas more moderate doses (800-1600 mg/kg) disrupted Pavlovian conditioning. These results parallel earlier observations that very low ethanol doses enhance Pavlovian conditioned eyeblink and heart rate responses in rabbits, and suggest that facilitation of Pavlovian conditioning may be a general effect of mild ethanol intoxication.
大鼠经过训练学会按压杠杆获取食物，然后在低剂量乙醇（不同组为0 - 1600毫克/千克）作用下接受厌恶性巴甫洛夫条件反射训练。在未进行额外差异处理的情况下，分别于48小时、7天和14天后对它们进行巴甫洛夫条件性杠杆按压抑制测试。结果显示，训练期间极低剂量的乙醇（约200毫克/千克）增强了后期的条件性抑制，而中等剂量（800 - 1600毫克/千克）则破坏了巴甫洛夫条件反射。这些结果与早期观察结果一致，即极低剂量的乙醇增强了兔子的巴甫洛夫条件性眨眼和心率反应，表明促进巴甫洛夫条件反射可能是轻度乙醇中毒的普遍效应。
