双锥几何结构中的X射线微调制发光断层扫描
X-ray micromodulated luminescence tomography in dual-cone geometry.
作者信息
Cong Wenxiang, Pan Zhengwei, Filkins Robert, Srivastava Alok, Ishaque Nadeem, Stefanov Plamen, Wang Ge
机构信息
Rensselaer Polytechnic Institute, Department of Biomedical Engineering, 110 8th Street, Troy, New York 12180.
University of Georgia, Department of Physics and Astronomy, Athens, Georgia 30602.
出版信息
J Biomed Opt. 2014;19(7):76002. doi: 10.1117/1.JBO.19.7.076002.
We propose a scanning method utilizing dual-cone beams of x-rays to induce luminescence from nanophosphors and reconstruct the three-dimensional distribution of these particles in a biological sample or a small animal. For this purpose, x-rays are focused through a polycapillary lens onto a spot of a few micrometers in size. Such x-ray scanning can be point-wise performed to acquire photon emission data on an object surface. The x-ray-induced luminescence data allow for reliable image reconstruction with high spatial resolution and large imaging depth. We describe several numerical simulation studies to demonstrate the feasibility and merits of the proposed approach.
我们提出一种扫描方法，利用双锥束X射线诱导纳米磷光体发光，并重建生物样本或小动物中这些粒子的三维分布。为此，X射线通过聚束透镜聚焦到几微米大小的光斑上。这种X射线扫描可以逐点进行，以获取物体表面的光子发射数据。X射线诱导的发光数据能够实现具有高空间分辨率和大成像深度的可靠图像重建。我们描述了几个数值模拟研究，以证明所提出方法的可行性和优点。
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