Vugts Danielle J, van Dongen Guus A M S
Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands.
Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands.
Drug Discov Today Technol. 2011 Summer;8(2-4):e53-61. doi: 10.1016/j.ddtec.2011.12.004.
(89)Zr-immuno-PET is an attractive option for the in vivo evaluation of monoclonal antibodies (mAbs). For the coupling of (89)Zr to monoclonal antibodies several conjugation strategies are available all using desferrioxamine as chelate. Here we discuss the production of (89)Zr, the available methods for coupling of (89)Zr via desferrioxamine to mAbs, and the evaluation of (89)Zr-mAb conjugates in preclinical and clinical studies.:
（89）Zr免疫正电子发射断层扫描（PET）是体内评估单克隆抗体（mAb）的一种有吸引力的选择。对于将（89）Zr与单克隆抗体偶联，有几种偶联策略可供选择，均使用去铁胺作为螯合剂。在此，我们讨论（89）Zr的生产、通过去铁胺将（89）Zr与mAb偶联的可用方法，以及在临床前和临床研究中对（89）Zr-mAb偶联物的评估。
