来自刺果苏木的新型决明烷型二萜类化合物。

New cassane-type diterpenoids from Caesalpinia bonduc.

作者信息

Wu Lin, Wang Xiaobing, Shan Siming, Luo Jun, Kong Lingyi

机构信息

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University.

出版信息

Chem Pharm Bull (Tokyo). 2014;62(7):729-33. doi: 10.1248/cpb.c14-00186.

DOI:10.1248/cpb.c14-00186

PMID:24990509

Abstract

Six new cassane diterpenoids, named caesalls H-M (1-6), were isolated from the seed kernels of Caesalpinia bonduc. Their structures were elucidated on the basis of spectroscopic analysis, mainly NMR and MS. The absolute configurations of compounds 1 and 3 were determined by a single-crystal X-ray study using a mirror CuKα radiation and circular dichroism (CD) spectra, respectively. None of the compounds were cytotoxic against HepG-2, MCF-7 and MG-63 cells.

摘要

从决明子的种子仁中分离出六种新的决明烷二萜类化合物，命名为决明素H-M（1-6）。它们的结构通过光谱分析，主要是核磁共振（NMR）和质谱（MS）来阐明。化合物1和3的绝对构型分别通过使用镜像CuKα辐射的单晶X射线研究和圆二色性（CD）光谱确定。这些化合物对HepG-2、MCF-7和MG-63细胞均无细胞毒性。