方金宁A - K，来自苏木种子的二萜类化合物
Phanginin A-K, diterpenoids from the seeds of Caesalpinia sappan Linn.
作者信息
Yodsaoue Orapun, Cheenpracha Sarot, Karalai Chatchanok, Ponglimanont Chanita, Chantrapromma Suchada, Fun Hoong-Kun, Kanjana-Opas Akkharawit
机构信息
Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
出版信息
Phytochemistry. 2008 Mar;69(5):1242-9. doi: 10.1016/j.phytochem.2007.11.013.
The first chemical study on the seeds of Caesalpinia sappan Linn. led to isolation of 11 cassane-type diterpenes, named phanginin A-K (1-11). The skeleton present in compounds 1-8 is rather unusual, consisting of a cassane-type diterpene with an ether bridge between C-19/C-20 in compounds 1-6 and C-11/C-20 in compounds 7 and 8. Their structures were elucidated on the basis of spectroscopic techniques. In addition, the X-ray structure of phanginin A (1) is reported. Only phanginin I (9) exhibited cytotoxic effect against KB cell line with IC50 value of 4.4 microg/ml.
对苏木种子的首次化学研究导致分离出11种决明烷型二萜，命名为方宁素A - K（1 - 11）。化合物1 - 8中存在的骨架相当不寻常，由一种决明烷型二萜组成，在化合物1 - 6中C - 19/C - 20之间有一个醚桥，在化合物7和8中C - 11/C - 20之间有一个醚桥。它们的结构是基于光谱技术阐明的。此外，还报道了方宁素A（1）的X射线结构。只有方宁素I（9）对KB细胞系表现出细胞毒性作用，IC50值为4.4微克/毫升。
Zotero 插件