Xing Yanlin, Wang Hong, Liu Xiaomei, Yu Xianyi, Chen Rui, Wang Ce, Yu Xuexin, Sun Le
Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, China.
Mol Biol Rep. 2014 Oct;41(10):6377-81. doi: 10.1007/s11033-014-3517-7. Epub 2014 Jul 3.
Kawasaki disease is a pediatric systemic vasculitis of unknown etiology, for which a genetic influence is suspected. But whether single nucleotide polymorphism (SNP) of caspase-3 rs72689236 is associated with Kawasaki disease is controversial. The aim of our study is to assess the association between the SNP of caspase-3 and risk for Kawasaki disease. We searched PubMed, MEDLINE, EMBASE, Springer, Elsevier Science Direct, Cochrane Library Google scholar, CNKI (China National Knowledge Infrastructure, in Chinese) and Wanfang database (in Chinese) to identify studies investigating the association between rs72689236 polymorphism and Kawasaki disease occurrence. There were five eligible studies, which included 4,241 (case group 1,560; control group 2,681) participants in this meta-analysis. Pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were calculated in a fixed-effects model (the Mantel-Haenszel method) or a random-effects model (the DerSimonian and Laird method) when appropriate. Significant associations were found under the overall ORs for A-allele comparison (A vs. G, pooled OR 1.33, 95 % CI 1.21-1.46), AA versus GG comparison (pooled OR 1.64, 95 % CI 1.35-2.00), GA versus GG comparison (pooled OR 1.42, 95 % CI 1.24-1.63), recessive model (AA vs. GG + GA, pooled OR 1.37, 95 % CI 1.15-1.64) and dominant model (AA + GA vs. GG, pooled OR 1.47, 95 % CI 1.29-1.67). This meta-analysis suggested that SNP rs72689236 of caspase-3 might be associated with susceptibility of Kawasaki disease and the allele A might increase the risk of Kawasaki disease in Asian samples such as Japanese and Chinese. In addition, individual studies with large sample size are needed to further evaluate the associations in various ethnic populations.
川崎病是一种病因不明的儿童系统性血管炎，怀疑存在遗传影响。但半胱天冬酶 - 3 rs72689236的单核苷酸多态性（SNP）是否与川崎病相关存在争议。我们研究的目的是评估半胱天冬酶 - 3的SNP与川崎病风险之间的关联。我们检索了PubMed、MEDLINE、EMBASE、Springer、Elsevier Science Direct、Cochrane图书馆、谷歌学术、中国知网（中文）和万方数据库（中文），以确定研究rs72689236多态性与川崎病发生之间关联的研究。有五项符合条件的研究，该荟萃分析共纳入4241名参与者（病例组1560名；对照组2681名）。在适当情况下，采用固定效应模型（Mantel - Haenszel法）或随机效应模型（DerSimonian和Laird法）计算合并比值比（OR）和95%置信区间（95%CI）。在A等位基因比较的总体OR下发现显著关联（A对G，合并OR 1.33，95%CI 1.21 - 1.46）、AA对GG比较（合并OR 1.64，95%CI 1.35 - 2.00）、GA对GG比较（合并OR 1.42，95%CI 1.24 - 1.63）、隐性模型（AA对GG + GA，合并OR 1.37，95%CI 1.15 - 1.64）和显性模型（AA + GA对GG，合并OR 1.47，95%CI 1.29 - 1.67）。该荟萃分析表明，半胱天冬酶 - 3的SNP rs72689236可能与川崎病易感性相关，且A等位基因可能增加日本和中国等亚洲样本中川崎病的发病风险。此外，需要开展大样本量的个体研究，以进一步评估不同种族人群中的关联。
