Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 165 Cathedral Street, Glasgow, G4 0RE, United Kingdom ; Science for Life Laboratory, Division of Translational Medicine & Chemical Biology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Stockholm, S-171 21, Sweden.
Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 165 Cathedral Street, Glasgow, G4 0RE, United Kingdom.
Beilstein J Org Chem. 2014 Jun 11;10:1333-8. doi: 10.3762/bjoc.10.135. eCollection 2014.
A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules.
已完成核苷 Q 前体（PreQ0）手性环戊基和环己基胺衍生物的收敛和立体选择性合成。该合成路线可高效制备具有有趣的三维特征的 4-取代类似物，包括手性环戊烷-1,2-二醇和-1,2,3-三醇衍生物。这种不寻常的取代模式为发现新型生物活性分子提供了有用的起点。
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