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使用手术阿普加评分来指导术后护理。

Use of the surgical Apgar score to guide postoperative care.

作者信息

Haddow J B, Adwan H, Clark S E, Tayeh S, Antonowicz S S, Jayia P, Chicken D W, Wiggins T, Davenport R, Kaptanis S, Fakhry M, Knowles C H, Elmetwally A S, Geddoa E, Nair M S, Naeem I, Adegbola S, Muirhead L J

机构信息

London Surgical Research Group.

出版信息

Ann R Coll Surg Engl. 2014 Jul;96(5):352-8. doi: 10.1308/003588414X13946184900840.

Abstract

INTRODUCTION

The surgical Apgar score (SAS) can predict 30-day major complications or death after surgery. Studies have validated the score in different patient populations and suggest it should be used to objectively guide postoperative care. We aimed to see whether using the SAS in a decisive approach in a future randomised controlled trial (RCT) would be likely to demonstrate an effect on postoperative care and clinical outcome.

METHODS

A total of 143 adults undergoing general/vascular surgery in 9 National Health Service hospitals were recruited to a pilot single blinded RCT and the data for 139 of these were analysed. Participants were randomised to a control group with standard postoperative care or to an intervention group with care influenced (but not mandated) by the SAS (decisive approach). The notional primary outcome was 30-day major complications or death.

RESULTS

Incidence of major complications was similar in both groups (control: 20/69 [29%], intervention: 23/70 [33%], p=0.622). Immediate admissions to the critical care unit was higher in the intervention group, especially in the SAS 0-4 subgroup (4/6 vs 2/7) although this was not statistically significant (p=0.310). Validity was also confirmed in area under the curve (AUC) analysis (AUC: 0.77).

CONCLUSIONS

This pilot study found that a future RCT to investigate the effect of using the SAS in a decisive approach may demonstrate a difference in postoperative care. However, significant changes to the design are needed if differences in clinical outcome are to be achieved reliably. These would include a wider array of postoperative interventions implemented using a quality improvement approach in a stepped wedge cluster design with blinded collection of outcome data.

摘要

引言

手术阿普加评分(SAS)可预测术后30天内的主要并发症或死亡情况。研究已在不同患者群体中验证了该评分,并表明其应用于客观指导术后护理。我们旨在探讨在未来的随机对照试验(RCT)中采用决定性方法使用SAS是否可能对术后护理和临床结局产生影响。

方法

来自9家国民保健服务医院的143例接受普通/血管外科手术的成年人被纳入一项单盲试验性RCT,其中139例患者的数据进行了分析。参与者被随机分为接受标准术后护理的对照组或接受受SAS影响(但非强制)的护理的干预组(决定性方法)。假定的主要结局为术后30天内的主要并发症或死亡。

结果

两组主要并发症的发生率相似(对照组:20/69 [29%],干预组:23/70 [33%],p = 0.622)。干预组入住重症监护病房的即时入院率较高,尤其是在SAS 0 - 4亚组中(4/6对2/7),尽管这无统计学意义(p = 0.310)。曲线下面积(AUC)分析也证实了其有效性(AUC:0.77)。

结论

这项试验性研究发现,未来一项探讨采用决定性方法使用SAS效果的RCT可能会在术后护理方面显示出差异。然而,若要可靠地实现临床结局的差异,则需要对设计进行重大改变。这些改变将包括采用质量改进方法,在阶梯式楔形整群设计中实施更广泛的术后干预措施,并采用盲法收集结局数据。

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