Bosso J A, Allen J E, Matsen J M
Department of Pharmacy Practice, College of Pharmacy, University of Utah, Salt Lake City 84112.
Antimicrob Agents Chemother. 1989 Apr;33(4):526-8. doi: 10.1128/AAC.33.4.526.
To detect a change in antibiotic susceptibility patterns in Pseudomonas aeruginosa isolates upon the introduction and clinical use of ciprofloxacin, aztreonam, and ceftazidime, MICs for clinical isolates collected before introduction of the antibiotics, during early clinical use, and later were determined for these and seven other antipseudomonal antibiotics. Concomitant resistance to two or more antibiotics was also studied. Over the three study periods, rates of susceptibility to 9 of the 10 antibiotics decreased. The largest decrease occurred with ceftazidime. Analysis of subsets of isolates from patients treated with ciprofloxacin or aztreonam also showed declining susceptibility to the latter but a stabilization of susceptibility to the former after an initial decline. Concomitant resistance within and among antibiotic classes was common.
为检测在环丙沙星、氨曲南和头孢他啶引入并临床使用后铜绿假单胞菌分离株抗生素敏感性模式的变化，测定了在这些抗生素引入前、临床早期使用期间及之后收集的临床分离株对这些抗生素以及其他七种抗假单胞菌抗生素的最低抑菌浓度（MIC）。还研究了对两种或更多种抗生素的同时耐药情况。在三个研究期间，10种抗生素中有9种的敏感率下降。头孢他啶的下降幅度最大。对接受环丙沙星或氨曲南治疗患者的分离株亚组分析也显示，对氨曲南的敏感性下降，但对环丙沙星的敏感性在最初下降后趋于稳定。抗生素类别内部和之间的同时耐药很常见。
