氨曲南、哌拉西林和替卡西林联合阿米卡星对来自囊性纤维化患儿的耐阿米卡星铜绿假单胞菌和洋葱伯克霍尔德菌分离株的体外活性。
In vitro activities of aztreonam, piperacillin, and ticarcillin combined with amikacin against amikacin-resistant Pseudomonas aeruginosa and P. cepacia isolates from children with cystic fibrosis.
作者信息
Aronoff S C, Klinger J D
出版信息
Antimicrob Agents Chemother. 1984 Feb;25(2):279-80. doi: 10.1128/AAC.25.2.279.
Abstract
Amikacin, combined with aztreonam, piperacillin, or ticarcillin, synergistically inhibited amikacin-resistant sputum isolates of Pseudomonas aeruginosa and P. cepacia from children with cystic fibrosis. Ticarcillin-amikacin was the least active combination. Aminoglycoside resistance should not preclude the use of beta-lactam-aminoglycoside combinations in the treatment of pulmonary infections in cystic fibrosis.
摘要
阿米卡星与氨曲南、哌拉西林或替卡西林联合使用时，可协同抑制囊性纤维化患儿痰液中对阿米卡星耐药的铜绿假单胞菌和洋葱伯克霍尔德菌分离株。替卡西林-阿米卡星组合的活性最低。在治疗囊性纤维化患者的肺部感染时，氨基糖苷类耐药不应排除使用β-内酰胺类-氨基糖苷类联合用药。
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