Wundt W, Lange K P, Baumgärtner M
Arzneimittelforschung. 1985;35(8):1322-5.
The in vitro activity of aztreonam, a synthetic monobactam, was evaluated against 245 strains of Pseudomonas aeruginosa, 130 of them being recent clinical isolates from patients and 115 from hospital environment. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and bactericidal kinetics were determined. The possibility of resistance development in vitro was studied. Gentamicin, cefsulodin, piperacillin and azlocillin were used as comparative agents with known antipseudomonal activity. At a concentration of 8 mg/l 83.3%, at 16 mg/l 92% of the tested strains were susceptible to aztreonam. Thus, the activity of aztreonam against Pseudomonas aeruginosa is equivalent to that of gentamicin and cefsulodin and better than that of piperacillin and azlocillin in terms of resistance. Bactericidal kinetics with fourfold MIC, which is equivalent to MBC, are nearly identical for aztreonam, piperacillin and cefsulodin. In vitro induced resistance additionally causes increased resistance against the other beta-lactam antibiotics.
对合成单环β-内酰胺类药物氨曲南的体外活性进行了评估，受试菌株为245株铜绿假单胞菌，其中130株为近期从患者中分离出的临床菌株，115株来自医院环境。测定了最低抑菌浓度（MIC）､最低杀菌浓度（MBC）和杀菌动力学。研究了体外产生耐药性的可能性。庆大霉素､头孢磺啶､哌拉西林和阿洛西林用作具有已知抗假单胞菌活性的对照药物。在浓度为8mg/L时，83.3%的受试菌株对氨曲南敏感，在16mg/L时，92%敏感。因此，就耐药性而言，氨曲南对铜绿假单胞菌的活性等同于庆大霉素和头孢磺啶，优于哌拉西林和阿洛西林。氨曲南､哌拉西林和头孢磺啶在四倍MIC（等同于MBC）时的杀菌动力学几乎相同。体外诱导的耐药性还会导致对其他β-内酰胺类抗生素的耐药性增加。
