Bel'skiĭ V V, Shatalaova E V
Antibiot Khimioter. 1989 Jan;34(1):31-4.
Antagonistic activity of 2 fresh isolates and 3 collection strains of Pseudomonas aeruginosa against 177 microbial strains was determined with the method of late antagonism. Among the microbial strains there were 56 staphylococcal strains isolated from patents and carriers. 38 nontypable colon bacilli isolated from healthy persons, 59 enteropathogenic colon bacilli of various serogroups, 12 strains of Proteus and 12 colon bacilli, carriers of multiple drug resistance factors (R factors). All the cultures were sensitive to the antagonistic action of 5 or at least 3 strains of Pseudomonas used in the study. The most active antagonists were the fresh isolates of Pseudomonas as compared to the collection strains. Among the staphylococci S. aureus proved to be the most resistant to the antagonistic action of Pseudomonas as compared to S. epidermidis, the same as the strains isolated from carriers as compared to the strains isolated from patients. As for the enteric bacilli the most resistant were the strains of Proteus. Acquiring of transmissive R factors by the colon bacilli markedly increased their sensitivity to the antagonistic action of Pseudomonas.
采用后期拮抗法测定了2株铜绿假单胞菌新鲜分离株和3株标准菌株对177株微生物的拮抗活性。这些微生物菌株中，有56株从患者和携带者中分离出的葡萄球菌菌株、38株从健康人分离出的不可分型大肠杆菌、59株不同血清群的肠道致病性大肠杆菌、12株变形杆菌菌株以及12株携带多重耐药因子（R因子）的大肠杆菌。所有培养物对研究中使用的5株或至少3株铜绿假单胞菌的拮抗作用敏感。与标准菌株相比，最具活性的拮抗剂是铜绿假单胞菌的新鲜分离株。在葡萄球菌中，与表皮葡萄球菌相比，金黄色葡萄球菌对铜绿假单胞菌的拮抗作用最具抗性，与从携带者中分离出的菌株相比，从患者中分离出的菌株也是如此。至于肠道杆菌，最具抗性的是变形杆菌菌株。大肠杆菌获得可传递的R因子后，其对铜绿假单胞菌拮抗作用的敏感性显著增加。
