Deforges L, Le Van Thoi J, Soussy C J, Duval J
Pathol Biol (Paris). 1985 May;33(5):301-8.
All strains of Staphylococcus aureus and Gram negative bacilli (Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter) isolated from 01.01 to 03.31.83 were studied using agar diffusion with augmentin-impregnated discs (amoxicillin 20 micrograms + clavulanic acid 10 micrograms). Augmentin is active against penicillinase-producing Staphylococci susceptible to methicillin, whereas methicillin-resistant strains are also resistant to augmentin. According to the susceptibility of strains to amoxicillin, carbenicillin and cefalotin, Enterobacteriaceae can be divided into five main phenotypes, of which four are resistant. "RSR" and "RRR" phenotypes, which are cephalosporinase producers, are chiefly found among Enterobacter, Serratia, Citrobacter and indole + Proteus; in these groups a change in inhibition diameters indicating activity of augmentin is observed only in a significant number of Proteus vulgaris strains. "RRS" and "RRI" strains are penicillinase producers found mainly among E. coli, Klebsiella pneumoniae and oxytoca, and Proteus mirabilis; they emerge as very susceptible to augmentin. Pseudomonas aeruginosa is never susceptible to augmentin. Augmentin is slightly more active than amoxicillin on some Acinetobacter strains but the difference is too inconsiderable to be of clinical significance.
对1983年1月1日至3月31日期间分离出的所有金黄色葡萄球菌菌株和革兰氏阴性杆菌（肠杆菌科、铜绿假单胞菌、不动杆菌），使用含阿莫西林克拉维酸钾的药敏纸片（阿莫西林20微克+克拉维酸10微克）进行琼脂扩散法研究。阿莫西林克拉维酸钾对产青霉素酶且对甲氧西林敏感的葡萄球菌有活性，而耐甲氧西林菌株对阿莫西林克拉维酸钾也耐药。根据菌株对阿莫西林、羧苄西林和头孢噻吩的敏感性，肠杆菌科可分为五种主要表型，其中四种耐药。“RSR”和“RRR”表型是头孢菌素酶产生菌，主要见于肠杆菌属、沙雷菌属、柠檬酸杆菌属和吲哚阳性变形杆菌；在这些菌属中，仅在大量普通变形杆菌菌株中观察到表明阿莫西林克拉维酸钾有活性的抑菌圈直径变化。“RRS”和“RRI”菌株是青霉素酶产生菌，主要见于大肠杆菌、肺炎克雷伯菌和产酸克雷伯菌以及奇异变形杆菌；它们对阿莫西林克拉维酸钾非常敏感。铜绿假单胞菌对阿莫西林克拉维酸钾从不敏感。阿莫西林克拉维酸钾对某些不动杆菌菌株的活性略高于阿莫西林，但差异太小，无临床意义。
