Choudary Srikanth A, Naik Archana R, Naik Madhukeshwara S, Anvitha D
Department of Periodontics, Dayananda Sagar College of Dental Sciences, Bangalore, India, .
Indian J Dent Res. 2014 Mar-Apr;25(2):220-4. doi: 10.4103/0970-9290.135928.
Peripheral ossifying fibroma (POF) is a solitary over growth of the gingiva known to arise from the cells of the periodontal ligament. The lesions usually start as a painless overgrowth of the interdental papilla unless associated with trauma and gradually involve the other counter parts of the gingiva. The lesion is more considered to be an inflammatory or reactive process rather than to be neoplastic. Here, the authors present a unique case of multiple POF in a young male adult aged 24 years where surgical excision was carried out quadrant wise. The biopsy specimen from multiple sites revealed similar histopathologic features consistent with POF, but also with the multicentric presentation of POF, which is a unique phenomenon. Multicentric variant of POF is indeed a rare case being only the second case so far which has been documented. Management of such case needs a multidisciplinary approach to prevent the recurrence along with regular long time follow-up.
外周骨化性纤维瘤（POF）是一种已知起源于牙周膜细胞的牙龈孤立性过度生长。病变通常始于齿间乳头的无痛性过度生长，除非与创伤有关，随后逐渐累及牙龈的其他部分。该病变更多地被认为是一种炎症或反应性过程，而非肿瘤性病变。在此，作者报告了一例24岁年轻男性成人的多发性POF独特病例，该病例采用象限切除术。来自多个部位的活检标本显示出与POF一致的相似组织病理学特征，同时也呈现出POF的多中心表现，这是一种独特现象。POF的多中心变体确实是罕见病例，迄今为止仅有第二例被记录。此类病例的管理需要多学科方法以防止复发，并进行长期定期随访。
