van Bockel Liselotte W, Verduijn Gerda M, Monninkhof Evelyn M, Pameijer Frank A, Terhaard Chris H J
University Medical Centre Utrecht, Department of Radiation Oncology, The Netherlands.
Erasmus Medical Centre, Department of Radiation Oncology, Rotterdam, The Netherlands.
Radiother Oncol. 2014 Jul;112(1):119-24. doi: 10.1016/j.radonc.2014.06.004. Epub 2014 Jun 30.
Evaluation of the variation in tumor growth rate and the influence of tumor growth rate on disease free survival (DFS) and overall survival (OS) in laryngeal squamous cell carcinoma (LSCC).
We delineated tumor volume on a diagnostic and planning CT scan in 131 patients with laryngeal squamous cell carcinoma and calculated the tumor growth rate. Primary endpoint was DFS. Follow up data were collected retrospectively.
A large variation in tumor growth rate was seen. When dichotomized with a cut-off point of -0.3 ln(cc/day), we found a significant association between high growth rate and worse DFS (p = 0.008) and OS (p = 0.013). After stepwise adjustment for potential confounders (age, differentiation and tumor volume) this significant association persisted. However, after adjustment of N-stage association disappeared. Exploratory analyses suggested a strong association between N-stage and tumor growth rate.
In laryngeal squamous cell carcinoma, there is a large variation in tumor growth rate. This tumor growth rate seems to be an important factor in disease free survival and OS. This tumor growth rate is independent of age, differentiation and tumor volume associated with DFS, but N-stage seems to be a more important risk factor.
评估喉鳞状细胞癌（LSCC）肿瘤生长速率的变化以及肿瘤生长速率对无病生存期（DFS）和总生存期（OS）的影响。
我们在131例喉鳞状细胞癌患者的诊断和计划CT扫描上勾勒出肿瘤体积，并计算肿瘤生长速率。主要终点是DFS。随访数据进行回顾性收集。
观察到肿瘤生长速率存在很大差异。当以-0.3 ln(cc/天)为分界点进行二分法分析时，我们发现高生长速率与较差的DFS（p = 0.008）和OS（p = 0.013）之间存在显著关联。在对潜在混杂因素（年龄、分化程度和肿瘤体积）进行逐步调整后，这种显著关联仍然存在。然而，在调整N分期后，关联消失。探索性分析表明N分期与肿瘤生长速率之间存在强烈关联。
在喉鳞状细胞癌中，肿瘤生长速率存在很大差异。这种肿瘤生长速率似乎是无病生存期和总生存期的一个重要因素。这种肿瘤生长速率独立于与DFS相关的年龄、分化程度和肿瘤体积，但N分期似乎是一个更重要的危险因素。
