Dussol Bertrand
Centre de néphrologie et de transplantation rénale, hôpital de la Conception, 147, boulevard Baille, 13385 Marseille cedex 05, France.
Nephrol Ther. 2014 Jul;10(4):246-57. doi: 10.1016/j.nephro.2014.05.004. Epub 2014 Jun 30.
Acid-base homeostasis ensured by the kidneys, which maintain the equilibrium between proton generation by cellular metabolism and proton excretion in urine. This requirement is lifesaving because of the protons' ability to bind to anionic proteins in the extracellular space, modifying their structure and functions. The kidneys also regenerate bicarbonates. The kidney is not the sole organ in charge of maintaining blood pH in a very narrow range; lungs are also involved since they allow a large amount of volatile acid generated by cellular respiration to be eliminated.
肾脏确保酸碱平衡，它维持着细胞代谢产生质子与尿液中质子排泄之间的平衡。这一需求关乎生命，因为质子能够与细胞外空间中的阴离子蛋白结合，改变其结构和功能。肾脏还能再生碳酸氢盐。肾脏并非负责将血液pH维持在非常狭窄范围内的唯一器官；肺也参与其中，因为它们能排出细胞呼吸产生的大量挥发性酸。
