Li Guojian, Liang Shujia, Harrison Tim J, Tang Zhenzhu, Shen Zhiyong, Wang Xueyan, Wu Xinghua, Liu Wei, Liang Fuxiong, Feng Liushuai, Yang Jinye, Fang Zhongliao
Department of Public Health of Guangxi Zhuang Autonomous Region, Nanning, China.
Intervirology. 2014;57(5):270-6. doi: 10.1159/000362366. Epub 2014 Jun 28.
Highly-active antiretroviral therapy (HAART) was scaled up in Guangxi, China in 2005. The number of individuals receiving free HAART increased dramatically from June 2010 under the Guangxi Government's anti-HIV programme. We aimed to determine the prevalence of HIV-transmitted drug resistance (TDR) of Guangxi.
HIV-positive, antiretroviral-naive individuals were recruited from the east (Hezhou), south (Qinzhou), west (Baise), north (Guilin) and centre (Laibin) of Guangxi. The pol gene of the virus from the individuals was analysed.
The overall prevalence of HIV TDR was 3.2% (7/216, 95% CI 0.9-5.5). The prevalence rates in Baise, Guilin, Hezhou, Qinzhou and Laibin are 4.9% (2/41, 95% CI -1.7 to 11.5), 2.3% (1/44, 95% CI -2.1 to 5.7), 4.7% (2/43, 95% CI -1.6 to 11.0), 2.6% (1/38, 95% CI -2.5 to 7.7) and 2.0% (1/50, 95% CI -1.9 to 5.9), respectively. No significant difference in the prevalence was found among them. No factors were found to be associated with TDR, including CD4 cell counts, viral loads and genotypes. The subtypes CRF01_AE, CRF07_BC, CRF08_BC and B were found. Subtype CRF08_BC is the predominant subtype in Baise while CRF01_AE is the predominant subtype elsewhere in Guangxi.
The prevalence of TDR in antiretroviral-naive patients in Guangxi remains low 8 years after scale-up of HAART.
高效抗逆转录病毒疗法（HAART）于2005年在中国广西扩大应用。自2010年6月起，在广西政府的抗艾滋病毒项目下，接受免费HAART治疗的人数急剧增加。我们旨在确定广西艾滋病毒传播耐药性（TDR）的流行情况。
从广西东部（贺州）、南部（钦州）、西部（百色）、北部（桂林）和中部（来宾）招募未接受过抗逆转录病毒治疗的艾滋病毒阳性个体。对这些个体的病毒pol基因进行分析。
艾滋病毒TDR的总体流行率为3.2%（7/216，95%置信区间0.9 - 5.5）。百色、桂林、贺州、钦州和来宾的流行率分别为4.9%（2/41，95%置信区间 - 1.7至11.5）、2.3%（1/44，95%置信区间 - 2.1至5.7）、4.7%（2/43，95%置信区间 - 1.6至11.0）、2.6%（1/38，95%置信区间 - 2.5至7.7）和2.0%（1/50，95%置信区间 - 1.9至5.9）。各地区之间的流行率无显著差异。未发现与TDR相关的因素，包括CD4细胞计数、病毒载量和基因型。发现了CRF01_AE、CRF07_BC、CRF08_BC和B亚型。CRF08_BC亚型是百色的主要亚型，而CRF01_AE亚型是广西其他地区的主要亚型。
HAART扩大应用8年后，广西未接受过抗逆转录病毒治疗患者的TDR流行率仍然较低。
