2004年前后中国初治HIV-1感染个体中的耐药流行情况。
The prevalence of drug resistance among treatment-naïve HIV-1-infected individuals in China during pre- and post- 2004.
作者信息
Li Hanping, Chang Shuai, Han Yang, Zhuang Daomin, Li Lin, Liu Yongjian, Liu Siyang, Bao Zuoyi, Zhang Wenfu, Song Hongbin, Li Taisheng, Li Jingyun
机构信息
State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Science, No. 20 East Street, Fengtai district, Beijing, 100071, China.
Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing, 100071, China.
出版信息
BMC Infect Dis. 2016 Oct 26;16(1):605. doi: 10.1186/s12879-016-1928-x.
BACKGROUND
The widespread use of antiretroviral therapies has led to considerable concerns about the prevalence of drug-resistant, as transmission of drug-resistant (TDR) strains poses a challenge for the control of the HIV-1 epidemic.
METHODS
We conducted an epidemiological study enrolling treatment-naïve HIV-1-positive subjects at the Peking Union Medical College Hospital since 1991. Drug resistance was determined by submitting the sequences to the Stanford University Network HIV-1 database.
RESULTS
Of 521 participants, 478 samples were amplified and sequenced successfully. HIV Transmitted drug resistance prevalence in China was determined to be 6.7 %. We did not find significant differences in the TDR rate by demographic characteristics. No significant time trend in the prevalence of overall TDR was observed (p > 0.05).
CONCLUSIONS
We identified an intermediate prevalence of transmitted drug resistance (TDR), exhibiting a stable time trend. These findings enhance our understanding of HIV-1 drug resistance prevalence and time trend, and provide some guidelines for the comprehensive public health strategy of TDR prevention.
背景
抗逆转录病毒疗法的广泛使用引发了人们对耐药性流行的严重担忧，因为耐药毒株的传播对控制HIV-1疫情构成了挑战。
方法
自1991年以来，我们在北京协和医院对未接受过治疗的HIV-1阳性受试者进行了一项流行病学研究。通过将序列提交至斯坦福大学HIV-1数据库来确定耐药性。
结果
在521名参与者中，478个样本成功扩增并测序。中国HIV传播耐药性患病率确定为6.7%。我们未发现按人口统计学特征划分的TDR率存在显著差异。未观察到总体TDR患病率有显著的时间趋势（p>0.05）。
结论
我们确定了传播耐药性（TDR）的中等患病率，呈现出稳定的时间趋势。这些发现增进了我们对HIV-1耐药性患病率和时间趋势的理解，并为TDR预防的综合公共卫生策略提供了一些指导方针。
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