Wu Jing Qin, Chen Da Chun, Tan Yun Long, Tan Shu Ping, Hui Li, Lv Men Han, Soares Jair C, Zhang Xiang Yang
School of Biomedical Sciences and Pharmacy, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia.
Psychopharmacology (Berl). 2015 Jan;232(1):223-32. doi: 10.1007/s00213-014-3660-9. Epub 2014 Jul 4.
Long-term antipsychotic treatment for schizophrenia is often associated with the emergence of tardive dyskinesia (TD), which is linked to greater cognitive impairment. Brain-derived neurotrophic factor (BDNF) plays a critical role in cognitive function, and schizophrenia patients with TD have lower BDNF levels than those without TD.
This study examines the BDNF levels, the cognitive function, and the association of BDNF with cognitive function in schizophrenia patients with or without TD.
We recruited 83 male chronic patients with (n=35) and without TD (n=48) meeting DSM-IV criteria for schizophrenia and 52 male control subjects. We examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and BDNF levels for all subjects. Positive and Negative Symptom Scale (PANSS) and the Abnormal Involuntary Movement Scale (AIMS) were assessed in patients.
BDNF levels were lower in patients with than those without TD (p<0.05). RBANS total score (p<0.01) and subscales of immediate memory, visuospatial/constructional performance, and attention were lower in patients with than those without TD (all p<0.05). BDNF levels were positively associated with immediate memory in patients without TD, but negatively in TD patients (both p<0.05). Multiple regression analysis confirmed that in either TD or non-TD group, BDNF was an independent contributor to immediate memory (both p<0.05).
BDNF may be involved in the pathophysiology of TD. While the associations between BDNF and cognition in both TD and non-TD patients suggest a close relationship between BDNF and cognition, the different directions may implicate distinct mechanisms between TD and non-TD patients.
精神分裂症的长期抗精神病药物治疗常与迟发性运动障碍（TD）的出现相关，而TD与更严重的认知障碍有关。脑源性神经营养因子（BDNF）在认知功能中起关键作用，患有TD的精神分裂症患者的BDNF水平低于未患TD的患者。
本研究调查了患有或未患TD的精神分裂症患者的BDNF水平、认知功能以及BDNF与认知功能之间的关联。
我们招募了83名符合精神分裂症DSM-IV标准的男性慢性患者，其中35名患有TD，48名未患TD，以及52名男性对照受试者。我们对所有受试者进行了可重复神经心理状态评估量表（RBANS）和BDNF水平检测。对患者评估了阳性与阴性症状量表（PANSS）和异常不自主运动量表（AIMS）。
患有TD的患者的BDNF水平低于未患TD的患者（p<0.05）。患有TD的患者的RBANS总分（p<0.01）以及即刻记忆、视觉空间/结构能力和注意力子量表得分均低于未患TD的患者（均p<0.05）。BDNF水平与未患TD患者的即刻记忆呈正相关，但与TD患者呈负相关（均p<0.05）。多元回归分析证实，在TD组或非TD组中，BDNF都是即刻记忆的独立影响因素（均p<0.05）。
BDNF可能参与了TD的病理生理过程。虽然TD患者和非TD患者中BDNF与认知之间的关联都表明BDNF与认知密切相关，但不同的方向可能暗示TD患者和非TD患者之间存在不同的机制。
