Department of Clinical Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave, Suite 340, Memphis, TN 38163, USA.
Int J Clin Pharm. 2012 Dec;34(6):822-4. doi: 10.1007/s11096-012-9685-4. Epub 2012 Aug 9.
The objective of this case report is to report the development of tardive dyskinesia in an African-American adolescent male after short-term treatment with metoclopramide 10 mg orally three times daily secondary to delayed gastric emptying. The patient developed symptoms of tardive dyskinesia after 2 days of therapy with metoclopramide. Metoclopramide was discontinued and diphenhydramine 50 mg was initially administered intravenously followed with 25 mg orally every 4 hours as needed. While there are case reports of drug-induced tardive dyskinesia after intravenous administration of metoclopramide, this is to our knowledge the first report of tardive dyskinesia after short-term treatment with oral metoclopramide in an adolescent.
Awareness of the risk of development of this adverse effect even with short-term treatment with metoclopramide and in younger patients is important.
本病例报告的目的是报告一例因胃排空延迟，短期接受每日三次，每次 10mg 口服甲氧氯普胺治疗后，出现迟发性运动障碍的非裔美国青少年男性病例。该患者在接受甲氧氯普胺治疗 2 天后出现迟发性运动障碍症状。停止使用甲氧氯普胺，并给予苯海拉明 50mg 静脉注射，随后按需每 4 小时口服 25mg。虽然有静脉注射甲氧氯普胺后出现药物引起的迟发性运动障碍的病例报告，但据我们所知，这是首例在青少年中短期口服甲氧氯普胺治疗后出现迟发性运动障碍的报告。
即使短期使用甲氧氯普胺治疗，且患者年龄较小，也应意识到发生这种不良反应的风险。
