MacLennan Louise, Moiemen Naiem
UK Healing Foundation Centre for Burns Research, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
UK Healing Foundation Centre for Burns Research, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
Burns. 2015 Feb;41(1):18-24. doi: 10.1016/j.burns.2014.06.001. Epub 2014 Jun 30.
The importance of cyanide toxicity as a component of inhalational injury in patients with burns is increasingly being recognised, and its prompt recognition and management is vital for optimising burns survival. The evidence base for the use of cyanide antidotes is limited by a lack of randomised controlled trials in humans, and in addition consideration must be given to the concomitant pathophysiological processes in patients with burns when interpreting the literature. We present a literature review of the evidence base for cyanide antidotes with interpretation in the context of patients with burns. We conclude that hydroxycobalamin should be utilised as the first-line antidote of choice in patients with burns with inhalational injury where features consistent with cyanide toxicity are present.
氰化物中毒作为烧伤患者吸入性损伤的一个组成部分,其重要性日益受到认可,对其迅速识别和处理对于提高烧伤患者的生存率至关重要。由于缺乏人体随机对照试验,氰化物解毒剂使用的证据基础有限,此外,在解读文献时,必须考虑烧伤患者伴随的病理生理过程。我们对氰化物解毒剂的证据基础进行了文献综述,并结合烧伤患者的情况进行解读。我们得出结论,对于存在与氰化物中毒相符特征的烧伤合并吸入性损伤患者,应将羟钴胺用作一线首选解毒剂。