Jegaskanda Sinthujan, Reading Patrick C, Kent Stephen J
Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia; and.
Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia; and World Health Organization Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria 3051, Australia.
J Immunol. 2014 Jul 15;193(2):469-75. doi: 10.4049/jimmunol.1400432.
There is an urgent need for universal influenza vaccines that can control emerging pandemic influenza virus threats without the need to generate new vaccines for each strain. Neutralizing Abs to the influenza virus hemagglutinin glycoprotein are effective at controlling influenza infection but generally target highly variable regions. Abs that can mediate other functions, such as killing influenza-infected cells and activating innate immune responses (termed "Ab-dependent cellular cytotoxicity [ADCC]-mediating Abs"), may assist in protective immunity to influenza. ADCC-mediating Abs can target more conserved regions of influenza virus proteins and recognize a broader array of influenza strains. We review recent research on influenza-specific ADCC Abs and their potential role in improved influenza-vaccination strategies.
迫切需要通用流感疫苗，这种疫苗能够控制新出现的大流行性流感病毒威胁，而无需针对每种毒株生产新疫苗。针对流感病毒血凝素糖蛋白的中和抗体在控制流感感染方面有效，但通常靶向高度可变区域。能够介导其他功能（如杀死流感感染细胞和激活先天免疫反应，称为“抗体依赖性细胞毒性[ADCC]介导抗体”）的抗体可能有助于对流感的保护性免疫。ADCC介导抗体可以靶向流感病毒蛋白的更多保守区域，并识别更广泛的流感毒株。我们综述了关于流感特异性ADCC抗体及其在改进流感疫苗接种策略中潜在作用的最新研究。
