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双膦酸盐相关颌骨坏死的新维度分期助力引导性手术治疗方案：来自巴里大学的肿瘤和骨质疏松症患者266处病变的长期随访

New dimensional staging of bisphosphonate-related osteonecrosis of the jaw allowing a guided surgical treatment protocol: long-term follow-up of 266 lesions in neoplastic and osteoporotic patients from the university of bari.

作者信息

Franco Simonetta, Miccoli Simona, Limongelli Luisa, Tempesta Angela, Favia Giorgio, Maiorano Eugenio, Favia Gianfranco

机构信息

Department of Interdisciplinary Medicine, Odontostomatology Unit, Faculty of Medicine, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.

Plastic, Reconstructive and Aesthetic Surgery Unit, Campus Bio-Medico University, Via Alvaro del Portillo 21, 00128 Rome, Italy.

出版信息

Int J Dent. 2014;2014:935657. doi: 10.1155/2014/935657. Epub 2014 Jun 5.

DOI:10.1155/2014/935657
PMID:24995017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4068095/
Abstract

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is the most serious side effect in patients receiving bisphosphonates (BPs) for neoplastic disease and osteoporosis. The aim of this study is to propose a new dimensional stage classification, guiding the surgical treatment of BRONJ patients, and to evaluate the success rate of this new management. From 2004 to 2013, 203 neoplastic and osteoporotic patients with 266 BRONJ lesions were referred to the Odontostomatology Unit of the University of Bari. All patients underwent surgery after suspension of BPs therapy and antibiotic treatment. The surgical procedure was complemented by piezosurgery and followed by the application of hyaluronate and amino acids. The new dimensional staging suggests the choice of the surgical approach, and allows the prediction of postoperative complications and soft and hard tissues healing time, guiding the surgical treatment protocol. This protocol could be a successful management strategy for BRONJ, considering the low recurrences rate and the good stabilisation of the surgical sites observed after a long-term follow-up.

摘要

双膦酸盐相关颌骨坏死（BRONJ）是接受双膦酸盐（BPs）治疗肿瘤疾病和骨质疏松症患者中最严重的副作用。本研究的目的是提出一种新的维度分期，指导BRONJ患者的外科治疗，并评估这种新治疗方法的成功率。2004年至2013年，203例患有266处BRONJ病变的肿瘤和骨质疏松症患者被转诊至巴里大学口腔颌面外科。所有患者在停用BPs治疗和抗生素治疗后接受手术。手术过程辅以压电手术，随后应用透明质酸盐和氨基酸。新的维度分期提示了手术方法的选择，并能预测术后并发症以及软硬组织愈合时间，指导手术治疗方案。考虑到长期随访后观察到的低复发率和手术部位的良好稳定性，该方案可能是BRONJ的一种成功治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/45392d2d2c44/IJD2014-935657.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/95fee75562a6/IJD2014-935657.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/264ee3170f85/IJD2014-935657.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/7d4154d5e262/IJD2014-935657.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/e982a9d5cca7/IJD2014-935657.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/8cf330437d65/IJD2014-935657.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/45392d2d2c44/IJD2014-935657.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/95fee75562a6/IJD2014-935657.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/264ee3170f85/IJD2014-935657.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/7d4154d5e262/IJD2014-935657.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/e982a9d5cca7/IJD2014-935657.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/8cf330437d65/IJD2014-935657.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c826/4068095/45392d2d2c44/IJD2014-935657.006.jpg

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Open Dent J. 2013 Aug 23;7:94-101. doi: 10.2174/1874210601307010094. eCollection 2013.
2
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3
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