Complex Unit of Odontostomatology, Interdisciplinary Department of Medicine, University Aldo Moro of Bari, 70121 Bari, Italy.
Department of Medical, Oral and Biotechnological Sciences, University Gabriele d'Annunzio, 66100 Chieti, Italy.
Int J Environ Res Public Health. 2023 Apr 5;20(7):5402. doi: 10.3390/ijerph20075402.
Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related side effect linked but not limited to antiresorptive and antiangiogenic molecules. It recognizes several triggers in dental procedures, such as surgery, endodontic treatments, and root planing, but also prosthesis decubitus or with a spontaneous onset. Although there are many reports about the onset of this pathology, oral hygiene status is mainly described as a consequence of MRONJ. Not so much is known about the oral hygiene situation as a concurrent factor in the pathogenesis of severe stages and about non-surgical periodontal therapy in patients affected by MRONJ. Actually, clear instructions for non-surgical periodontal therapy are poor in the literature. The primary outcome of the present study is to evaluate the oral hygiene status in MRONJ patients. In addition, a secondary outcome is to review the factor of poor oral hygiene as a cause or worsening aspect for MRONJ. A total of 45 subjects (19 males and 26 females) with a mean age of 59 ± 12 were enrolled. The Pearson correlation coefficient showed no significant results for the variable of the Simplified Oral Hygiene Index (OHI-S) and the American Association of Oral and Maxillofacial Surgeons (AAOMS) stage, although the majority of patients showed poor oral hygiene with an OHI-S average of 3.39 ± 1.83. As stated by the last AAOMS position paper, poor plaque control is related to a worsened MRONJ stage. The relation between the lack of oral hygiene and MRONJ onset is still unclear.
药物相关性颌骨坏死（MRONJ）是一种与药物相关的副作用，不仅与抗吸收和抗血管生成分子有关。它认识到几种在牙科手术中的触发因素，如手术、根管治疗和根面平整，但也与义齿卧床或自发性发病有关。尽管有许多关于这种病理学发病的报道，但口腔卫生状况主要被描述为 MRONJ 的后果。关于口腔卫生状况作为严重阶段发病机制的并发因素以及 MRONJ 患者非手术牙周治疗的了解并不多。实际上，文献中对非手术牙周治疗的明确指导很差。本研究的主要结果是评估 MRONJ 患者的口腔卫生状况。此外，次要结果是回顾不良口腔卫生状况作为 MRONJ 的原因或恶化方面的因素。共纳入 45 名受试者（19 名男性和 26 名女性），平均年龄为 59±12 岁。Pearson 相关系数显示简化口腔卫生指数（OHI-S）和美国口腔颌面外科学会（AAOMS）分期的变量之间没有显著结果，尽管大多数患者的口腔卫生状况较差，OHI-S 平均为 3.39±1.83。正如最后一份 AAOMS 立场文件所述，不良的菌斑控制与 MRONJ 分期恶化有关。口腔卫生不良与 MRONJ 发病之间的关系尚不清楚。
