Wang Le-Min, Duan Qiang-Lin, Yi Xiang-Hua, Zeng Yu, Gong Zhu, Yang Fan
Department of Cardiology, Tongji Hospital of Tongji University School of Medicine Shanghai 200065, China.
Department of Pathology, Tongji Hospital of Tongji University School of Medicine Shanghai 200065, China.
Int J Clin Exp Med. 2014 May 15;7(5):1319-23. eCollection 2014.
The pathogenesis of venous thromboembolism (VTE) in patients with cancer is related to the destruction of small veins and the intravenous formation of filamentous mesh-like structure by fibrinogen. The filamentous mesh-like filter can block hematogenous metastasis of cancer cells and also can stagnate blood cells, leading to venous thrombosis. Cancer cells have characteristics of malignancy and fast proliferation, and ischemic necrosis frequently occurs, and small veins were invaded and damaged. The formation of filamentous mesh-like structure has defense function and also may cause the occurrence of VTE. VTE is a product of the proliferation process of malignant cells.
癌症患者静脉血栓栓塞（VTE）的发病机制与小静脉破坏以及纤维蛋白原在静脉内形成丝状网状结构有关。丝状网状滤网可阻断癌细胞的血行转移，也可使血细胞淤滞，导致静脉血栓形成。癌细胞具有恶性和快速增殖的特性，常发生缺血性坏死，小静脉受到侵犯和损害。丝状网状结构的形成具有防御功能，也可能导致VTE的发生。VTE是恶性细胞增殖过程的产物。
