Shetty Sanyuktha, K Sharath, Thomas Biju, Shetty Nitin, Shetty Arvind, Shetty Devanand
Senior Lecturer, Department of Periodontics, Dr. D.Y. Patil Dental College & Hospital , Nerul, Navi Mumbai, India .
Professor and Head, Department of Periodontics, Srinivas Institute of Dental Sciences , Mukka, Karnataka, India .
J Clin Diagn Res. 2014 May;8(5):ZC17-20. doi: 10.7860/JCDR/2014/7805.4344. Epub 2014 May 15.
To evaluate and compare the clinical effects of ibuprofen and diclofenac sodium on bleeding during periodontal surgery.
Thirteen medically healthy men and women of mean age 37.5±17.67 (mean age± standard deviation) were selected for the study. All the subjects were divided into three groups: control (C) and test groups (T1) and (T2). Each subject of T1 group and T2 group was given ibuprofen and diclofenac sodium respectively, prior to surgery. Bleeding times of patients were recorded prior to performance of periodontal flap surgical procedures.
It was found that there was increased bleeding time and increased peri-operative bleeding when ibuprofen and diclofenac sodium were taken prior to surgery and this was statistically significant. (2.5538 (T1), 1.8385 (T2) versus 1.2385 (C) minute, p= .001) (mean blood loss) and (62.0325 ± 9.0594 (T1), 51.082 ± 9.792 (T2) versus 37.4992 ± 5.99 (C) millilitre, p = .000).
The findings of this study suggested that pre-operative administration of ibuprofen and diclofenac sodium could increase bleeding time and peri - operative blood loss.
评估并比较布洛芬和双氯芬酸钠对牙周手术中出血的临床效果。
选择13名年龄平均为37.5±17.67岁（平均年龄±标准差）的身体健康的男性和女性进行研究。所有受试者分为三组：对照组（C）以及试验组（T1）和（T2）。T1组和T2组的每位受试者在手术前分别给予布洛芬和双氯芬酸钠。在进行牙周瓣手术前记录患者的出血时间。
发现在手术前服用布洛芬和双氯芬酸钠时，出血时间延长且围手术期出血量增加，这具有统计学意义。（T1组为2.5538分钟，T2组为1.8385分钟，而C组为1.2385分钟，p = .001）（平均失血量）以及（T1组为62.0325±9.0594毫升，T2组为51.082±9.792毫升，而C组为37.4992±5.99毫升，p = .000）。
本研究结果表明，术前给予布洛芬和双氯芬酸钠会增加出血时间和围手术期失血量。
