1型和2型糖尿病患者以及年龄匹配的健康对照者的血清白细胞介素-17、白细胞介素-23和转化生长因子-β水平。
Serum IL-17, IL-23, and TGF-β levels in type 1 and type 2 diabetic patients and age-matched healthy controls.
作者信息
Roohi Azam, Tabrizi Mina, Abbasi Farzaneh, Ataie-Jafari Asal, Nikbin Behrouz, Larijani Bagher, Qorbani Mostafa, Meysamie Alipasha, Asgarian-Omran Hossein, Nikmanesh Bahram, Bajouri Arezou, Shafiey Novin, Maleki Akram
机构信息
Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran ; Endocrinology and Metabolism Research Center (EMRC), Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran 1411413137, Iran ; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
出版信息
Biomed Res Int. 2014;2014:718946. doi: 10.1155/2014/718946. Epub 2014 Jun 4.
Type 1 diabetes is recognized as an autoimmune inflammatory disease and low grade inflammation is also observed in type 2 diabetic patients. Interleukin 17 (IL-17) is a new player in inflammation. Th17 cells, as the main source of IL-17, require transforming growth factor β (TGF-β) and interleukin 23 (IL-23). The aim of this study was to investigate serum IL-17, IL-23 and TGF-β levels in diabetic patients and controls. In this case-control study, serum levels of IL-17, IL-23, and TGF-β were measured in 24 type 1 diabetic patients and 30 healthy controls using the ELISA method. Simultaneously, the same methodology was used to compare serum concentration of these three cytokines in 38 type 2 diabetic patients and 40 healthy controls. There was no significant difference between serum levels of IL-17 and IL-23 cytokines between cases and controls. However, TGF-β was significantly lower in type 1 diabetic patients (P < 0.001). Serum IL-17 and IL-23 levels demonstrate no association with type 1 and type 2 diabetes, but, in line with previous studies, TGF-β levels were lower in type 1 diabetic patients.
1型糖尿病被认为是一种自身免疫性炎症性疾病，2型糖尿病患者也存在低度炎症。白细胞介素17（IL-17）是炎症中的一个新因素。作为IL-17的主要来源，Th17细胞需要转化生长因子β（TGF-β）和白细胞介素23（IL-23）。本研究的目的是调查糖尿病患者和对照组血清中IL-17、IL-23和TGF-β的水平。在这项病例对照研究中，采用酶联免疫吸附测定（ELISA）法检测了24例1型糖尿病患者和30例健康对照者血清中IL-17、IL-23和TGF-β的水平。同时，采用相同方法比较了38例2型糖尿病患者和40例健康对照者血清中这三种细胞因子的浓度。病例组和对照组血清中IL-17和IL-23细胞因子水平无显著差异。然而，1型糖尿病患者的TGF-β水平显著降低（P < 0.001）。血清IL-17和IL-23水平与1型和2型糖尿病无关联，但与先前研究一致，1型糖尿病患者的TGF-β水平较低。
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