Darmochwal-Kolarz Dorota, Michalak Magdalena, Kolarz Bogdan, Przegalinska-Kalamucka Monika, Bojarska-Junak Agnieszka, Sliwa Dariusz, Oleszczuk Jan
Department of Gynecology and Obstetrics, Institute of Clinical and Experimental Medicine, Medical Faculty, University of Rzeszow, Rzeszow, Poland.
Department of Obstetrics and Perinatology, Medical University of Lublin, Lublin, Poland.
Biomed Res Int. 2017;2017:6904325. doi: 10.1155/2017/6904325. Epub 2017 Jun 15.
The aim of the study was to evaluate the role of Interleukin-17 (IL-17), Interleukin-23 (IL-23), and transforming growth factor- (TGF-) in pregnancy complicated by placental insufficiency and in normal pregnancy.
The study comprised 34 patients with pregnancy complicated by fetal growth restriction (FGR) associated with preeclampsia (PE), as well as 35 healthy pregnant women. The concentrations of IL-17, IL-23, and TGF- in sera from maternal peripheral blood were determined by an immunoenzymatic assay.
There were higher concentrations of IL-17 in the study group when compared to the controls. In the group of patients with placental insufficiency, the levels of IL-17 positively correlated with systolic blood pressure ( = 0.42, < 0.01). The study obtained comparable concentrations of IL-23 in both studied groups. The concentrations of TGF- were significantly lower in pregnancy complicated by the insufficiency of placenta when compared to the controls.
It seems possible that the increased concentrations of IL-17 and the deficiency of TGF- in pregnancy complicated by FGR and PE can be responsible for the activation of inflammatory response observed in PE cases.
本研究旨在评估白细胞介素-17（IL-17）、白细胞介素-23（IL-23）和转化生长因子-（TGF-）在合并胎盘功能不全的妊娠及正常妊娠中的作用。
本研究包括34例合并胎儿生长受限（FGR）及子痫前期（PE）的妊娠患者，以及35例健康孕妇。采用免疫酶法测定母体外周血血清中IL-17、IL-23和TGF-的浓度。
与对照组相比，研究组中IL-17的浓度更高。在胎盘功能不全的患者组中，IL-17水平与收缩压呈正相关（=0.42，<0.01）。本研究在两个研究组中获得了相当的IL-23浓度。与对照组相比，合并胎盘功能不全的妊娠中TGF-的浓度显著降低。
在合并FGR和PE的妊娠中，IL-17浓度升高和TGF-缺乏可能是导致PE病例中观察到的炎症反应激活的原因。
