Centre of Expertise for Industrial Biotechnology and Biocatalysis, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, 9000 Gent, Belgium.
Centre of Expertise for Industrial Biotechnology and Biocatalysis, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, 9000 Gent, Belgium.
Curr Opin Biotechnol. 2014 Dec;30:66-72. doi: 10.1016/j.copbio.2014.06.002. Epub 2014 Jul 1.
In the recent years, biosurfactants proved to be an interesting alternative to petrochemically derived surfactants. Two classes of biosurfactants, namely glycolipids and lipopeptides, have attracted significant commercial interest. Despite their environmental advantages and equal performance, commercialization of these molecules remains a challenge due to missing acquaintance of the applicants, higher price and lack of structural variation. The latter two issues can partially be tackled by screening for novel and better wild-type producers and optimizing the fermentation process. Yet, these traditional approaches cannot overcome all hurdles. In this review, an overview is given on how biotechnology offers opportunities for increased biosurfactant production and the creation of new types of molecules, in this way enhancing their commercial potential.
近年来,生物表面活性剂被证明是石油化学衍生表面活性剂的一种很有前途的替代品。两类生物表面活性剂,即糖脂和脂肽,引起了人们的极大商业兴趣。尽管它们具有环境优势且性能相当,但由于申请人缺乏了解、价格较高以及缺乏结构变化,这些分子的商业化仍然是一个挑战。后两个问题可以通过筛选新型和更好的野生型生产菌并优化发酵工艺来部分解决。然而,这些传统方法并不能克服所有障碍。在这篇综述中,概述了生物技术如何为提高生物表面活性剂的产量和创造新型分子提供机会,从而提高它们的商业潜力。