Jakobi P, Krivoy N, Eibschitz I, Ziskind G, Barzilai D, Paldi E
Departments of Obstetrics/Gynecology B, Rambam Medical Center, Haifa, Israel.
J Clin Endocrinol Metab. 1989 Jul;69(1):209-11. doi: 10.1210/jcem-69-1-209.
Plasma digoxin-like immunoreactive factor(s) (DLIF) have been reported in various pathophysiological conditions associated with volume expansion and linked to the regulation of blood volume and pressure. We hypothesized that DLIF might be present in rapidly expanding gonadotropin-stimulated ovarian follicles. The mean total and free DLIF concentrations in the follicles (n = 9) studied were 4925 nmol/L and 1885 nmol/L, respectively. These concentrations were substantially higher than the plasma total and free DLIF levels in these women: 1216 nmol/L and 158 nmol/L, respectively (p less than 0.0001). The plasma DLIF levels in the gonadotropin-treated women were comparable to those in term pregnant women, which are known to be higher than those in non-pregnant women. The ovary thus may be a source of DLIF in the plasma of gonadotropin-treated women, and DLIF may have a role in ovarian follicular fluid homeostasis.
血浆中类地高辛免疫反应因子（DLIF）已在与容量扩张相关的各种病理生理状况中被报道，并与血容量和血压的调节有关。我们推测DLIF可能存在于促性腺激素刺激的快速扩张的卵巢卵泡中。所研究的卵泡（n = 9）中的平均总DLIF浓度和游离DLIF浓度分别为4925 nmol/L和1885 nmol/L。这些浓度显著高于这些女性血浆中的总DLIF水平和游离DLIF水平，分别为1216 nmol/L和158 nmol/L（p < 0.0001）。接受促性腺激素治疗的女性的血浆DLIF水平与足月孕妇的相当，已知足月孕妇的血浆DLIF水平高于非孕妇。因此，卵巢可能是接受促性腺激素治疗的女性血浆中DLIF的来源，并且DLIF可能在卵巢卵泡液稳态中起作用。
