Department of Reproductive Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Department of Obstetrics and Gynecology, Spaarne Hospital, Hoofddorp, the Netherlands.
Fertil Steril. 2014 Sep;102(3):821-5. doi: 10.1016/j.fertnstert.2014.05.042. Epub 2014 Jul 1.
To determine whether hysterosalpingo-foam sonography (HyFoSy) is a less painful first line tubal patency test than serial hysterosalpingography (HSG).
A two-center, prospective, open-label, randomized, controlled trial.
University hospital and teaching hospital.
PATIENT(S): 40 subfertile women, ages 18 to 41 years, with an indication for tubal patency testing as part of the fertility workup according to the Dutch Nederlandse Vereniging voor Obsteterie & Gynaecologie-guidelines.
INTERVENTION(S): Tubal patency testing by HyFoSy versus serial HSG.
MAIN OUTCOME MEASURE(S): Visual Analogue Scale (VAS) pain scores during tubal patency testing.
RESULT(S): The median VAS score for pain perception during the HyFoSy procedure was 1.7 cm (interquartile range: 2.1) compared with 3.7 cm (interquartile range: 4.2) during HSG. The HyFoSy procedure also had a statistically significantly shorter procedure time compared with HSG, with a median of 5.0 minutes (interquartile range: 3.0) for HyFoSy versus 12.5 minutes (interquartile range: 16.0) for HSG.
CONCLUSION(S): The HyFoSy procedure is a less painful and less time-consuming tubal patency test compared with HSG.
Netherlands National Trial Register NTR3457.
比较宫腔内双氧水超声造影（HyFoSy）与子宫输卵管造影（HSG），以明确前者是否为一种较不痛苦的一线输卵管通畅性检查方法。
一项两中心、前瞻性、开放标签、随机对照临床试验。
大学医院和教学医院。
40 名年龄 18 至 41 岁的不孕女性，根据荷兰妇产科协会指南，有进行输卵管通畅性检查的指征。
HyFoSy 与 HSG 用于输卵管通畅性检查。
输卵管通畅性检查过程中的视觉模拟评分（VAS）疼痛评分。
HyFoSy 组输卵管通畅性检查过程中的 VAS 评分中位数为 1.7cm（四分位间距：2.1），而 HSG 组为 3.7cm（四分位间距：4.2）。与 HSG 相比，HyFoSy 组的手术时间也明显更短，中位数分别为 5.0 分钟（四分位间距：3.0）和 12.5 分钟（四分位间距：16.0）。
与 HSG 相比，HyFoSy 是一种更不痛苦、耗时更短的输卵管通畅性检查方法。
荷兰国家临床试验注册库 NTR3457。
