Amarteifio E, Essig M, Böckler D, Attigah N, Schuster L, Demirel S
Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; Department of Radiology, German Cancer Research Center (dkfz), Heidelberg, Germany.
Department of Radiology, University of Manitoba, GA216-820 Sherbrook Street, MB R3T 2N2 Manitoba, Winnipeg, Canada.
J Neuroradiol. 2015 Jul;42(4):236-44. doi: 10.1016/j.neurad.2014.03.002. Epub 2014 Jul 1.
To prove superiority of blood pool contrast agent gadofosveset over conventional contrast agent gadobenate dimeglumine for assessment of stenotic internal carotid artery (ICA).
Eleven patients with high-grade ICA stenosis (≥75%), confirmed by duplex sonography, underwent MR angiography (MRA) with gadofosveset and gadobenate dimeglumine.
Agreement in stenosis grade was reached in 7 of 10 stenotic ICAs. In two ICAs, gadobenate dimeglumine led to underestimation of stenosis grade. There was a significant difference in signal intensity (pre-/post-stenotic segments), showing higher values for gadofosveset (P<0.01; P<0.05). Impression of contrast intensity with gadofosveset was better in 8 ICAs and only in 1 ICA with gadobenate dimeglumine (P<0.05).
Gadofosveset-enhanced MR angiography may be superior for assessment of high-grade ICA stenosis compared with gadobenate dimeglumine MR angiography.
证明血池造影剂钆布醇在评估颈内动脉（ICA）狭窄方面优于传统造影剂钆贝葡胺。
11例经双功超声证实为重度ICA狭窄（≥75%）的患者接受了使用钆布醇和钆贝葡胺的磁共振血管造影（MRA）检查。
10处狭窄的ICA中，有7处狭窄分级达成一致。在2处ICA中，钆贝葡胺导致狭窄分级低估。信号强度（狭窄前/后节段）存在显著差异，钆布醇的值更高（P<0.01；P<0.05）。8处ICA中钆布醇的造影剂强化效果更佳，而钆贝葡胺仅在1处ICA中效果较好（P<0.05）。
与钆贝葡胺磁共振血管造影相比，钆布醇增强磁共振血管造影在评估重度ICA狭窄方面可能更具优势。
