Calmels B, Boulanger F, Baudoux E, Decot V, Fawaz A, Giraud C, Hivert B, Garderet L, Milpied N, Yakoub-Agha I
Centre de thérapie cellulaire et génique, institut Paoli-Calmettes, 232, boulevard Sainte-Marguerite, BP 156, 13273 Marseille cedex 09, France; EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France.
EFS Nord de France, laboratoire de thérapie cellulaire, 96, rue de Jemmapes, CS 22018, 59013 Lille cedex, France; EFS centre atlantique, site de Poitiers, 350, avenue Jacques-Cœur, BP 482, 86012 Poitiers cedex, France.
Pathol Biol (Paris). 2014 Aug;62(4):221-5. doi: 10.1016/j.patbio.2014.05.006. Epub 2014 Jul 1.
Thousands of autologous and at less extent allogeneic hematopoietic stem cells (HSC) bags are cryopreserved in France. The majority of autologous HSC grafts are used within a year after collection. However, many bags are still unused and cryopreserved for many years. In France and on a European scale, the ever-growing number of cryopreserved bags represents a real economic health concern. Indeed, the cost of storage is about 100€ per bag and per year. In addition, quality and therapeutic value of these long-term cryopreserved grafts needs to be evaluated. In the attempt to harmonize clinical practices between different French transplantation centers, the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC) set up its fourth annual series of workshops which brought together practitioners from its member centers across France. These workshops took place in September 2013 in Lille. In this article, we addressed the issue of the destruction of long-term cryopreserved grafts be them autologous or allogeneic and provide recommendations regarding their destruction.
在法国，数千个自体造血干细胞（HSC）袋以及数量较少的异体造血干细胞袋被冷冻保存。大多数自体造血干细胞移植物在采集后的一年内使用。然而，仍有许多袋子多年未使用且一直处于冷冻保存状态。在法国乃至欧洲范围内，冷冻保存袋子数量的不断增加成为了一个切实的经济健康问题。事实上，存储成本约为每袋每年100欧元。此外，这些长期冷冻保存移植物的质量和治疗价值需要评估。为了协调法国不同移植中心之间的临床实践，法国骨髓移植与细胞治疗协会（SFGM-TC）举办了第四届年度系列研讨会，来自法国各地会员中心的从业者齐聚一堂。这些研讨会于2013年9月在里尔举行。在本文中，我们探讨了长期冷冻保存移植物（无论是自体还是异体）的销毁问题，并就其销毁提供了建议。
