Vural Yilmaz Zehra, Gencosmanoglu Turkmen Gulenay, Daglar Korkut, Yılmaz Elif, Kara Ozgur, Uygur Dilek
Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey.
Ginekol Pol. 2017;88(2):75-80. doi: 10.5603/GP.a2017.0015.
Intrahepatic cholestasis of pregnancy is the most common pregnancy specific liver disease and related with adverse maternal and perinatal outcome. Red blood cell distribution width, an anisocytosis marker in a complete blood count, has been used as an inflammation marker in various diseases. However the association of red blood cell distribution width with intrahepatic cholestasis of pregnancy is unknown. We aimed to evaluate the relationship between red blood cell distribution width and intrahepatic cholestasis of pregnancy.
Ninety pregnant women with intrahepatic cholestasis of pregnancy and ninety healthy pregnant women were included in the study. Their clinical and laboratory characteristics including red blood cell distribution width, liver function tests, fasting and postprandial bile acid concentrations were analyzed.
Serum red blood cell distribution width cell levels were significantly higher in pregnants with intrahepatic cholestasis of pregnancy than healthy pregnants. We also demonstrated that red blood cell distribution Width levels were higher in severe disease than mild disease and was significantly correlated with fasting and postprandial bile acid concentration in intrahepatic cholestasis of pregnancy group.
Our study showed that red blood cell distribution width, an easy and inexpensive marker; were associated with intrahepatic cholestasis of pregnancy and can be used as a diagnostic and prognostic marker in intrahepatic cholestasis of pregnancy.
妊娠期肝内胆汁淤积症是最常见的妊娠特异性肝病，与不良的孕产妇和围产儿结局相关。红细胞分布宽度是全血细胞计数中的一项红细胞大小不均一性指标，已被用作多种疾病的炎症标志物。然而，红细胞分布宽度与妊娠期肝内胆汁淤积症之间的关联尚不清楚。我们旨在评估红细胞分布宽度与妊娠期肝内胆汁淤积症之间的关系。
本研究纳入了90例妊娠期肝内胆汁淤积症孕妇和90例健康孕妇。分析了她们的临床和实验室特征，包括红细胞分布宽度、肝功能检查、空腹和餐后胆汁酸浓度。
妊娠期肝内胆汁淤积症孕妇的血清红细胞分布宽度水平显著高于健康孕妇。我们还证明，严重疾病患者的红细胞分布宽度水平高于轻度疾病患者，并且在妊娠期肝内胆汁淤积症组中与空腹和餐后胆汁酸浓度显著相关。
我们的研究表明，红细胞分布宽度作为一种简便且廉价的指标，与妊娠期肝内胆汁淤积症相关，可作为妊娠期肝内胆汁淤积症的诊断和预后指标。
