Gabbai Daniel, Gilboa Itamar, Lavie Anat, Yogev Yariv, Attali Emmanuel
Lis Hospital for Women's Health, Tel Aviv Sourasky Medical Centre, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
BJOG. 2025 Sep;132(10):1454-1459. doi: 10.1111/1471-0528.18208. Epub 2025 May 8.
To evaluate the association between maternal neutrophil-to-lymphocyte ratio (NLR) and delivery within 24 h in women with preterm premature rupture of membranes (PPROM).
Retrospective cohort study in a single university-affiliated tertiary medical centre.
Women with PPROM at ≤ 36 + 6 weeks' gestation planning vaginal delivery. Exclusions included women who lacked complete blood count (CBC) data within the first 24 h from PPROM caesarean delivery.
Maternal demographic and clinical data, including age, gestational age, body mass index, parity and mode of conception, were collected. Women who delivered within 24 h of membrane rupture were compared to those who did not via univariate and multivariate Cox analyses.
Women who delivered within 24 h from rupture of membrane.
Among 145 833 deliveries during the study period, 1498 women (0.9%) presented with PPROM. After exclusions, 371 women were included, with 173 (46.6%) delivering spontaneously within 24 h. Cox regression analysis identified NLR > 10 (HR = 1.60; 95% CI, 1.06-2.40; p = 0.025) as an independent risk factor for spontaneous delivery within 24 h.
Elevated maternal NLR is associated with delivery within 24 h in PPROM and may support clinical assessment for anticipating imminent preterm delivery, aiding in management decisions for this population.
评估胎膜早破（PPROM）孕妇的母体中性粒细胞与淋巴细胞比值（NLR）与24小时内分娩之间的关联。
在一所大学附属三级医疗中心进行的回顾性队列研究。
妊娠≤36⁺⁶周计划阴道分娩的PPROM孕妇。排除标准包括在PPROM剖宫产术后24小时内缺乏全血细胞计数（CBC）数据的孕妇。
收集产妇的人口统计学和临床数据，包括年龄、孕周、体重指数、产次和受孕方式。通过单因素和多因素Cox分析，比较胎膜破裂后24小时内分娩的妇女与未在24小时内分娩的妇女。
胎膜破裂后24小时内分娩的妇女。
在研究期间的145833例分娩中，1498例妇女（0.9%）发生PPROM。排除后，纳入371例妇女，其中173例（46.6%）在24小时内自然分娩。Cox回归分析确定NLR>10（HR=1.60；95%CI，1.06-2.40；p=0.025）是24小时内自然分娩的独立危险因素。
母体NLR升高与PPROM孕妇24小时内分娩有关，可能有助于临床评估即将到来的早产情况，辅助该人群的管理决策。
