Kotey Stanley, Ertel Karen, Whitcomb Brian
School of Public Health and Health Sciences, University of Massachusetts Amherst, 715 N. Pleasant Street, Amherst, MA, 01003, USA,
J Autism Dev Disord. 2014 Dec;44(12):3083-8. doi: 10.1007/s10803-014-2174-y.
Few large epidemiological studies have examined the co-occurrence of autism and asthma. We performed a cross-sectional study to examine this association using the 2007 National Survey of Children's Health dataset (n = 77,951). We controlled for confounders and tested for autism-secondhand smoke interaction. Prevalence of asthma and autism were 14.5 % (n = 11,335) and 1.81 % (n = 1,412) respectively. Unadjusted odds ratio (OR) for asthma among autistic children was 1.35 (95 % CI 1.18-1.55). Adjusting for covariates (age, gender, body mass index, race, brain injury, secondhand smoke and socio-economic status) attenuated the OR to 1.19 (95 % CI 1.03-1.36). Autism-secondhand smoke interaction was insignificant (p = 0.38). Asthma is approximately 35 % more common in autistic children; screening may be an efficient approach to reduce risk of morbidity due to asthma.
很少有大型流行病学研究调查过自闭症和哮喘的共现情况。我们利用2007年全国儿童健康调查数据集（n = 77,951）进行了一项横断面研究来调查这种关联。我们对混杂因素进行了控制，并测试了自闭症与二手烟的相互作用。哮喘和自闭症的患病率分别为14.5%（n = 11,335）和1.81%（n = 1,412）。自闭症儿童患哮喘的未调整优势比（OR）为1.35（95%置信区间1.18 - 1.55）。对协变量（年龄、性别、体重指数、种族、脑损伤、二手烟和社会经济地位）进行调整后，优势比降至1.19（95%置信区间1.03 - 1.36）。自闭症与二手烟的相互作用不显著（p = 0.38）。自闭症儿童患哮喘的几率大约高35%；筛查可能是降低哮喘发病风险的有效方法。
