2-氯亚苄基丙二腈（CS）会导致V79中国仓鼠细胞中的纺锤体紊乱。
2-Chlorobenzylidene malonitrile (CS) causes spindle disturbances in V79 Chinese hamster cells.
作者信息
Schmid E, Bauchinger M, Ziegler-Skylakakis K, Andrae U
机构信息
Institut für Strahlenbiologie, Gesellschaft für Strahlen- und Umweltforschung, Neuherberg/Munich, F.R.G.
出版信息
Mutat Res. 1989 Jun;226(2):133-6. doi: 10.1016/0165-7992(89)90056-0.
Exposure of V79 Chinese hamster cells to 2-chlorobenzylidene malonitrile (CS), a chemical used as a sensory irritant for riot control, caused a concentration-dependent increase in the incidence of spindle disturbances. A C-mitotic effect with the appearance of C-metaphases, a metaphase block and the concomitant disappearance of ana-telophase figures were observed after a 3-h treatment. The results indicate that CS might induce aneuploidy in mammalian cells by interacting with the mitotic apparatus.
将V79中国仓鼠细胞暴露于2-氯亚苄基丙二腈（CS），一种用作防暴感官刺激剂的化学品，导致纺锤体紊乱发生率呈浓度依赖性增加。在3小时处理后，观察到具有C中期出现的C有丝分裂效应、中期阻滞以及后期-末期图像的伴随消失。结果表明，CS可能通过与有丝分裂装置相互作用在哺乳动物细胞中诱导非整倍体。
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