Leung Yinko S S L, Thanassoulis G, Stark K D, Avgil Tsadok M, Engert J C, Pilote L
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
Division of Clinical Epidemiology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada; Division of Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.
Nutr Metab Cardiovasc Dis. 2014 Nov;24(11):1234-9. doi: 10.1016/j.numecd.2014.06.001. Epub 2014 Jun 13.
Recent gene-environment interaction studies suggest that diet may influence an individual's genetic predisposition to cardiovascular risk. We evaluated whether omega-3 fatty acid intake may influence the risk for acute coronary syndrome (ACS) conferred by genetic polymorphisms among patients with early onset ACS.
Our population consisted of 705 patients of white European descent enrolled in GENESIS-PRAXY, a multicenter cohort study of patients aged 18-55 years and hospitalized with ACS. We used a case-only design to investigate interactions between the omega-3 index (a validated biomarker of omega-3 fatty acid intake) and 30 single nucleotide polymorphisms (SNPs) robustly associated with ACS. We used logistic regression to assess the interaction between each SNP and the omega-3 index. Interaction was also assessed between the omega-3 index and a genetic risk score generated from the 30 SNPs. All models were adjusted for age and sex. An interaction for increased ACS risk was found between carriers of the chromosome 9p21 variant rs4977574 and low omega-3 index (OR 1.57, 95% CI 1.07-2.32, p = 0.02), but this was not significant after correction for multiple testing. Similar results were obtained in the adjusted model (OR 1.55, 95% CI 1.05-2.29, p = 0.03). We did not observe any interaction between the genetic risk score or any of the other SNPs and the omega-3 index.
Our results suggest that omega-3 fatty acid intake may modify the genetic risk conferred by chromosome 9p21 variation in the development of early onset ACS and requires independent replication.
近期的基因-环境相互作用研究表明，饮食可能会影响个体患心血管疾病风险的遗传易感性。我们评估了ω-3脂肪酸摄入量是否会影响早发性急性冠状动脉综合征（ACS）患者中基因多态性所赋予的急性冠状动脉综合征（ACS）风险。
我们的研究对象包括705名欧洲白种人后裔患者，他们参与了GENESIS-PRAXY研究，这是一项针对18至55岁因ACS住院患者的多中心队列研究。我们采用病例对照设计，研究ω-3指数（一种经过验证的ω-3脂肪酸摄入量生物标志物）与30个与ACS密切相关的单核苷酸多态性（SNP）之间的相互作用。我们使用逻辑回归评估每个SNP与ω-3指数之间的相互作用。还评估了ω-3指数与由这30个SNP生成的遗传风险评分之间的相互作用。所有模型均根据年龄和性别进行了调整。在9号染色体p21变体rs4977574的携带者与低ω-3指数之间发现了ACS风险增加的相互作用（比值比1.57，95%置信区间1.07 - 2.32，p = 0.02），但在多重检验校正后并不显著。在调整模型中也得到了类似结果（比值比1.55，95%置信区间1.05 - 2.29，p = 0.03）。我们未观察到遗传风险评分或任何其他SNP与ω-3指数之间存在任何相互作用。
我们的结果表明，ω-3脂肪酸摄入量可能会改变9号染色体p21变异在早发性ACS发生发展过程中所赋予的遗传风险，这需要独立验证。
