Department of Cardiology, Center for Cardiovascular Research, Aalborg, Denmark.
Circulation. 2011 Sep 13;124(11):1232-8. doi: 10.1161/CIRCULATIONAHA.110.987057. Epub 2011 Aug 22.
Marine n-3 polyunsaturated fatty acids may reduce coronary mortality. Previous data in relation to nonfatal coronary disease, however, have been inconsistent, which may be explained by the use of heterogeneous methods to assess the intake of marine n-3 polyunsaturated fatty acids. We investigated the hypothesis that the content of total and individual marine n-3 polyunsaturated fatty acids in adipose tissue is negatively associated with the incidence of acute coronary syndrome (ACS), including both fatal and nonfatal coronary disease.
In the Diet, Cancer and Health, a Danish cohort study, 57 053 subjects were enrolled and had an adipose tissue biopsy taken at inclusion. During a mean follow-up period of 7.6 years, we identified and verified all cases (n=1012) with an incident acute coronary syndrome diagnosis, and a random sample of the cohort (n=1630) had their fatty acid composition in adipose tissue determined by gas chromatography. We found negative dose-response associations between the content of total marine n-3 polyunsaturated fatty acids and individual n-3 polyunsaturated fatty acids in adipose tissue and the risk of acute coronary syndrome. Comparing men in the highest and lowest quintiles gave a hazard ratio of 0.65 (95% confidence interval, 0.45 to 0.95) for total n-3 polyunsaturated fatty acids and 0.51 (95% confidence interval, 0.36 to 0.73) for docosahexaenoic acid. Nonfatal cases constituted >86% of cases, and the association was driven primarily by a reduction in the risk of nonfatal acute coronary syndrome. No consistent associations were found among women.
Intake of marine n-3 polyunsaturated fatty acids may protect against acute coronary syndrome in men.
海洋 n-3 多不饱和脂肪酸可能降低冠心病死亡率。然而，先前关于非致命性冠心病的数据并不一致，这可能是由于采用了评估海洋 n-3 多不饱和脂肪酸摄入的异质方法来解释。我们研究了这样一个假设，即脂肪组织中总海洋 n-3 多不饱和脂肪酸和单个海洋 n-3 多不饱和脂肪酸的含量与急性冠状动脉综合征（ACS）的发生率呈负相关，包括致命性和非致命性冠心病。
在丹麦的一项队列研究——饮食、癌症和健康研究中，纳入了 57053 名受试者，并在纳入时进行了脂肪组织活检。在平均 7.6 年的随访期间，我们确定并验证了所有（n=1012）急性冠状动脉综合征病例，并对队列中的随机样本（n=1630）进行了气相色谱法检测其脂肪组织中的脂肪酸组成。我们发现脂肪组织中总海洋 n-3 多不饱和脂肪酸和单个 n-3 多不饱和脂肪酸的含量与急性冠状动脉综合征风险之间呈负剂量反应关系。比较最高和最低五分位组的男性，总 n-3 多不饱和脂肪酸的危险比为 0.65（95%置信区间，0.45 至 0.95），二十二碳六烯酸的危险比为 0.51（95%置信区间，0.36 至 0.73）。非致命性病例占病例的>86%，且该关联主要是由于非致命性急性冠状动脉综合征风险降低所致。在女性中未发现一致的相关性。
海洋 n-3 多不饱和脂肪酸的摄入可能对男性急性冠状动脉综合征有保护作用。
